Abstract
Investigators at Emory University, Atlanta, GA and multiple centers in the USA and UK conducted a prospective study of the effects of antiepileptic drug (AED) monotherapy (carbamazepine, lamotrigine, phenytoin, or valproate) on the intelligence quotient (IQ) at 6 years of age (age-6 IQ).
Highlights
Investigators at Emory University, Atlanta, GA and multiple centers in the USA and UK conducted a prospective study of the effects of antiepileptic drug (AED) monotherapy on the intelligence quotient (IQ) at 6 years of age
Measures of verbal and memory abilities were lower in children exposed to valproate compared to the other AEDs, and non-verbal and executive functions were lower with valproate compared to lamotrigine
High doses of valproate were negatively associated with IQ, verbal ability, non-verbal ability, memory, and executive function; other AEDs were not
Summary
Mutational screening for neonatal and infantile seizures should involve KCNQ2 in both BFNS and BFNIS, and PRRT2 in BFIS families. A clear clinical classification of the seizure phenotype is an essential preliminary to genetic analysis. In addition to confirming a clinical diagnosis, a positive SCN1A mutation will influence treatment and improve seizure control. (Brunklaus A, et al The clinical utility of an SCN1A genetic diagnosis in infantile-onset epilepsy.
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