Abstract
Medical carbon material has been extensively studied due to their excellent biological and mechanical properties. However, the dissociation of the surface carbon particles greatly limited the application of medical carbon material (MCM). To overcome this defect, we introduced the polydimethylsiloxane, a polymer-coating material (PCM) that possesses acceptable biocompatibility, into medical carbon material to prevent the shedding of carbon debris. Additionally, to reduce inflammatory reactions and increase surface hydrophilicity, ferulic acid, also called Chinese medicine coating material (CCM), was used to modify the surface of polymer-coating material. We investigated the proliferation and adhesion of NIH-3T3 cells onto MCM, PCM and CCM in vitro. We showed that CCM exhibited excellent biological activity to promote cell growth. Twelve weeks after CCM implantation, bone defects were repaired, and the material showed acceptable chemical stability. The results indicated that the CCM composite possesses excellent mechanical property and favorable biocompatibility, which can be used for clinical bone repair.
Highlights
In recent years, the incidence of joint trauma caused by accidents or diseases has been increasing annually[1]
We introduced the polydimethylsiloxane, a polymer-coating material (PCM) that possesses acceptable biocompatibility, into medical carbon material to prevent the shedding of carbon debris
The composite carbon material was prepared with PDMS, by soaking for a long time to be completely packed by PDMS
Summary
The incidence of joint trauma caused by accidents or diseases has been increasing annually[1]. Owing to the limited self-repair capacity of bone tissue, joint injury will severely affect the quality of life of patients. Treatment of these injuries often requires surgery, which carries the risk of infections. With the improvement of medical technology, various composite materials are used in fabricating artificial joint prosthesis in orthopedic surgery, such as ceramic[2], bioactive glass[3] and metal[4], etc. Medical carbon material (MCM) is usually used as joint prosthesis biomaterials due to excellent biocompatibility and mechanical properties. It was reported that the main mechanical property of medical carbon material is more similar to that of natural bone than other common bone repair materials[5]. Studies have shown that carbon particles produced by friction are often released from the interface between the implant and surrounding bone[6]
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