Fertility Inhibitor Heterobimetallic Complexes of Platinum(II) and Palladium(II): Synthetic, Spectroscopic and Antimicrobial Aspects

Kripa Sharma,R V Singh,S C Joshi

doi:10.1155/mbd.2000.105

Abstract

Synthetic, spectroscopic and antimicrobial aspects of some fertility inhibitor heterobimetallic complexes have been carried out. These heterobimetallic chelates [M(C5H5N3)2M2'(R)4]Cl2 (M = Pd or Pt and M' = Si, Sn, Ti and Zr) have been successfully synthesinzed via the reaction of M(C5H7N3)2Cl2 with group four or fourteen dichlorides in 1:2 stoichiometric proportions. The products were characterized by elemental analyses, molecular weight determinations, magnetic susceptibility measurements, conductance, and IR multinuclear NMR and electronic spectral studies. A square planar geometry has been suggested for all the complexes with the help of spectral data. Conductivity data strongly suggest that chlorine atoms are ionic in nature due to which complexes behave as electrolytes. All the complexes have been evaluated for their antmicrobial effects on different species of pathogenic fungi and bacteria. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs have been examined and discussed.

Highlights

The complexes of metal ions with macrocyclic ligands are significant because of their resemblance with many natural systems, such as porphyrins and cobalamines[2]
The excess of the solvent was removed under reduced pressure and the complexes were dried for 3-4 hours in vacuo
The elemental analysis and spectral data are consistent with the formulations of the compounds as

Summary

INTRODUCTION

The complexes of metal ions with macrocyclic ligands are significant because of their resemblance with many natural systems, such as porphyrins and cobalamines[2]. Meaningful research in this direction might generate simple models for biologically occurring metallo enzymes and will help in developing our understanding of biological systems These ligands are of theoretical interest as they are capable of furnishing an environment of controlled geometry and ligand field strength4"7. A literature survey disclosed that a number of polydentate macrocyclic ligands and their metal complexes have been reported[8]. Their electronic properties and reactivities are ressemble those of porphyrins. Transition metal complexes of nitrogen donor ligands have been studied in detail on account of their interesting stereochemistry and wide practical utility.[20 21] Transition metals and their complexes have evolved great interest due to their biological potential22’2 unusual structural aspects, unique stereo and magneto chemistry 24 and ability to form multiple complexes. In view of the above facts it was considered as useful to synthesize such a type of compounds with an aim to characterize them structurally, electrochemically and biologically

MATERIALS AND METHODS

Analytical Methods and Physical Measurements

RESULTS AND DISCUSSION