Abstract
The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron. In Hodgkin's disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release. Increased concentrations of circulating ferritin have also been observed in a few cases of chronic leukaemia and myelomatosis.
Highlights
Summary.-The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease
They bances of erythropoiesis and iron meta- noted ferritin in the serum of patients bolism, and the present investigation was with acute myeloid leukaemia
The mean ferritin concentration of patients with acute myeloblastic leukaemia is about 10 times normal and the highest value was 2,200 ng/ml compared with the highest normal value of 186 ng/ml
Summary
The range of values for haematological data were: Haemoglobin 2 6- 119 (mean 8.3) g/100 ml; total leucocyte count 800-252,000 (mean 33,393) cells/1ul; platelets 12,000-96,000 (mean 44,878)/y1; serum iron 40-282 (mean 139). Eighteen of these patients had a total white cell count of less than 10,000/1A. Haemoglobin 7-2-15-8 (mean 12.5) g/100 ml; serum iron 20-128 (mean 49) ytg/100 ml; transferrin saturation 7-34 (mean 15-3)oo. The differences in these parameters in Stages I-IV were not significant. Haemoglobin concentration 11-2-12 0 (mean 11 5) g/1(00 ml, serum iron 70-136 (mean 105) ,ug/100 ml, transferrin saturation 24-45 (mean 32) 0, total white count 124,000-282,000 (mean 177,000) cells/Ul. 6.
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