Abstract
A fine structural investigation of the transport of intravenously-injected ferritin (110 Å) through the external vascular barrier (choriocapillaris and Bruch's membrane) of the Japanese quail retina has been sequentially detailed. One minute after injection ferritin is found mainly within the vascular lumina of the choriocapillaris but also is seen in pinocytic vesicles within the capillary endothelium and dispersed throughout the various components of Bruch's membrane. Ferritin transport through the capillary endothelium appears to occur via pinocytic vesicles in the thickened portions and diaphragmatic pores (single and double) in the attenuated areas. Within 5–10 min post-injection ferritin is observed within the basal infoldings of the pigment epithelium.
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