Abstract
Ferritin is an iron-containing protein found in normal tissues; it increases in concentration in many tumors and in the blood of multiple-myeloma patients. In this chronobiological study, we have examined the temporal behavior of serum ferritin in multiple myeloma and in benign monoclonal gammopathy. All patients were kept under the same standard conditions, and 6 venous samples were taken at 4-hour intervals starting at 8.00 a.m. Serum ferritin was determined by an immunoradiometric procedure. Ferritin levels and the various rhythm parameters were analyzed by the ‘group mean cosinor’. The data suggest that the circadian rhythm of ferritin can be used as a marker in the monitoring of multiple myeloma and in the discrimination between benign and malignant monoclonal gammopathies.
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