Ferrite Nanoparticles-Based Reactive Oxygen Species-Mediated Cancer Therapy.

Shancheng Yu,Haiming Fan,Mingli Zhong,Shiya Zhang,Huan Zhang

doi:10.3389/fchem.2021.651053

Shancheng Yu, Haiming Fan + Show 3 more

Open Access

https://doi.org/10.3389/fchem.2021.651053

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Abstract

Ferrite nanoparticles have been widely used in the biomedical field (such as magnetic targeting, magnetic resonance imaging, magnetic hyperthermia, etc.) due to their appealing magnetic properties. In tumor acidic microenvironment, ferrite nanoparticles show intrinsic peroxidase-like activities, which can catalyze the Fenton reaction of hydrogen peroxide (H2O2) to produce highly toxic hydroxyl free radicals (•OH), causing the death of tumor cell. Recent progresses in this field have shown that the enzymatic activity of ferrite can be improved via converting external field energy such as alternating magnetic field and near-infrared laser into nanoscale heat to produce more •OH, enhancing the killing effect on tumor cells. On the other hand, combined with other nanomaterials or drugs for cascade reactions, the production of reactive oxygen species (ROS) can also be increased to obtain more efficient cancer therapy. In this review, we will discuss the current status and progress of the application of ferrite nanoparticles in ROS-mediated cancer therapy and try to provide new ideas for this area.

Highlights

Cancer is one of the principal causes of morbidity and mortality in every country of the world
We summarized the advances in the application of ferrite nanoparticles in ROSmediated cancer therapy, and constructive perspectives were provided
Radiation promoted the production of the superoxide anion in mitochondria, which was further converted to hydrogen peroxide by superoxide dismutase, and the generated H2O2 could be catalyzed to the highly reactive hydroxyl radical by the Fenton reaction with iron oxide nanoparticles for the enhancement of radiation therapy

Summary

Introduction

Cancer is one of the principal causes of morbidity and mortality in every country of the world. Relying on the intrinsic Fenton reaction catalytic activity of ferrite nanomaterials often requires a high concentration to generate enough ROS to kill tumor cells, which may increase the burden of iron removal based on the kidney and liver and cause adverse damage to the body (Ranji-Burachaloo et al, 2018).

Results

Conclusion