Abstract
This paper describes the preparation and obtained magnetic properties of large single domain iron oxide nanoparticles. Such ferrimagnetic particles are particularly interesting for diagnostic and therapeutic applications in medicine or (bio)technology. The particles were prepared by a modified oxidation method of non-magnetic precursors following the green rust synthesis and characterized regarding their structural and magnetic properties. For increasing preparation temperatures (5 to 85 °C), an increasing particle size in the range of 30 to 60 nm is observed. Magnetic measurements confirm a single domain ferrimagnetic behavior with a mean saturation magnetization of ca. 90 Am2/kg and a size-dependent coercivity in the range of 6 to 15 kA/m. The samples show a specific absorption rate (SAR) of up to 600 W/g, which is promising for magnetic hyperthermia application. For particle preparation temperatures above 45 °C, a non-magnetic impurity phase occurs besides the magnetic iron oxides that results in a reduced net saturation magnetization.
Highlights
Magnetic iron oxide nanoparticles (MNPs) are of great interest for hyperthermia applications as a therapeutic approach mainly for tumor diseases [1,2,3,4,5], utilizing their unique feature of heat generation when placed in an external alternating magnetic field caused by the reorientation of the magnetic moment of the particle
In Transmission electron microscopy (TEM), we found no influence of synthesis temperature on the uniformity of the large single domain iron oxide particles (LSDPs), but concerning the particle shape, smaller particles are more sphere-like, whereas larger ones show a deviation from the spherical shape due to pronounced crystalline facets
In TEM, we found no influence of synthesis temperature on the on the uniformity of the LSDPs, but concerning the particle particles are uniformity of the LSDPs, but concerning the particle shape, shape, smallersmaller particles are more more sphere-like, whereas larger ones show a deviation from the spherical shape due to sphere-like, whereas larger ones show a deviation from the spherical shape due to pro◦ C and the pronounced crystalline facets
Summary
Magnetic iron oxide nanoparticles (MNPs) are of great interest for hyperthermia applications as a therapeutic approach mainly for tumor diseases [1,2,3,4,5], utilizing their unique feature of heat generation when placed in an external alternating magnetic field caused by the reorientation of the magnetic moment of the particle. In this medical setting, strict limits have to be met concerning the applied magnetic field to ensure patient safety. Technical hyperthermia applications can include thermoresponsive shape memory polymers with
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