Abstract
Ideal materials for bone regeneration should have not only a good bioactivity, but also a good mechanical strength to provide an initial support for new bone formation. How to get a balance between high mechanical property and good bioactivity is a challenging issue for bone regeneration materials. In the present work, a biocompatible additive Fe2O3 was selected to optimize the comprehensive properties of a novel calcium phosphate silicate (CPS) ceramic using a mechanical mixing method. The effects of Fe2O3 content on microstructure, bending strength, apatite formation ability and cytocompatibility of Fe-CPS bioceramics were investigated and the related mechanism was also discussed. The obtained Fe-CPS bioceramics showed enhanced mechanical and favorable bioactivity performances. Especially, the Fe-CPS bioceramic with 1.5 wt% Fe2O3 sintered at 1250 °C presented the highest bending strength of 91.9 MPa. While, Fe-CPS bioceramics still exhibited a good ability on apatite formation in simulated body fluid (SBF), and cytocompatibility test revealed that Fe-CPS bioceramics were favorable for cell adhesion and proliferation. All the results indicated that Fe-CPS bioceramics are promising candidate materials for bone regeneration at load bearing applications.
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