Fermented Medicinal Plant Designed by Lactobacillus Hits Alternative Complement Pathway and Controlled hA1c Level

Abstract

Background: A Type II Diabetes mellitus showed many symptoms that brought serious for the patients. One of the problem was suppressed activity of the phagocyte for the foreign microorganism. Objective: The objective of this study was to find excellent method to recover the suppressed phagocytic cell activity both in animal and human. Methods: A wild medicinal herbs were prepared by Yeast and Lactobaccilli against 80 sorts of wild plants including medicinal remedies (FWP80). These products were exhibited by safe in animal safety test. The trial was made to investigate a recovery of immune-competent cells both in mice and human that exhibited phagocytic depression. Results: Our results in animal model showed that FWP80 augmented the macrophage activity, both chemotaxis and phagocytosis. In clinical study with 20 volunteers diagnosed type II DM, the granulocyte and lymphocyte ratio was produced to as modulate as neutral, 30 days after the introduction by FWP80. Conclusion: In mice, depressed phagocytic cell by Streptozotocin, the macrophage activities were recovered by FWP80. We proposed an idea that FWP80 exhibited remedy effect via controlling complement component. The mechanism of activation was proved by activating alternative pathway of complement by the technic, immuneelectrophoresis. We tried to evaluate more to the anti-oxidative activities of FWP80, directory employing peritoneal macrophage in vivo.