Abstract
A plant fermentation was carried out by Yeast and Lactobaccilli against fermented black turmeric, Kaempferia parviflora (FBT). These materials were proved by as safe in animal safety experiment. We tried to investigate changes of immune-competent cells that commonly utilized FBT, including after administration of immno-suppressed animals, the effects by FBT on the regulated effect on the cells were evaluated. Our results showed that FBT augmented the level of lymphocytes in number, while FBT regulated the level of granulocytes in both number and function. In our clinical study with 20 healthy volunteers, granulocyte and lymphocyte ratio suggesting their constitution as neutral in peripheral blood were increased significantly 30 days after the administration of FBT in rodents, and compromised host was prepared with cancer chemotherapeutic agent (Mytomycin-C). Our observations showed against intracellular parasite, and that FBT augmented intercellular pathogen through humoral immunity. We discussed the significance and mechanism of FBT on the level of leukocyte subsets in number and function that were considered to be potential indicators for the activation of the compromised host. We also proposed an idea that FBT exhibited tonic effects via activating complement components. The evidences were shown by immune-electrophoretic method. Moreover, we tried to access further to the anti-oxidative activities of this FBT. This modification brought to the significant lift up for antibody producing cells and anti-oxidative activity for phagocytic cells.
Highlights
In recent years, complementary and alternative medicines (CAM) have achieved more and more attentions since they are able to treat many chronic illnesses, such as fatigue syndrome that plagues the industrialized world
For qualitative and quantitative evaluation, we examined the cytokine expression levels, and directly measured the expression levels of cytokine-containing cells in peripheral blood, eliminating possible artificial factors that could arise from culturing in test tubes or changes in net value by catalyzation
We confirmed that FBT quantitatively and qualitatively regulated leukocytes, granulocytes, lymphocytes and their subsets
Summary
Complementary and alternative medicines (CAM) have achieved more and more attentions since they are able to treat many chronic illnesses, such as fatigue syndrome that plagues the industrialized world. The present team has reported that typical styles of CAM, preparing special molecule for both digestive and easy for activate human complement component. The activated complement components bound to regulate function of all the leukocytein humanimmune system [1]-[7]. We hypothesize that FBT may influence immuno-competent cells qualitatively and quantitatively FBT targeting lymphocytes based on the constitution dependent manner. We seek to focus on the identity of FBT formula, comparing to another herbal medicine. The influence of FBT on leukocyte and/or lymphocyte subpopulations in human peripheral blood was discussed. Fragmentation of black turmeric has been made by Lactobacillus and by Yeast Fungus in order to induce active component from original material other than dairy use [9] Figure 1, Figure 2
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