Abstract
METHODS After obtaining IRB approval, a retrospective cohort study was conducted using anesthetic records and medical charts of infants who underwent surgical closure of PDA between September 2001 and June 2003. Patient demographics, preoperative status, anesthetic technique and postoperative course were evaluated. The reviewer was blinded to outcome. Unstable Postoperative Respiratory Course (UPRC) was defined as respiratory instability requiring an increase in FiO2 > 25, or an increase in pulmonary inspiratory pressure > 3 cm H2O compared to preoperative baseline, or requirement for manual ventilation with 100% oxygen. The total fentanyl dose used for general anesthesia was compared against UPRC. Differences were assessed using a T-test.
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