Abstract
Background: Ischemia/reperfusion (I/R) injury is a potentially devastating condition, associated with a systemic inflammatory response. It occurs during shock, transplant procedures, or vascular surgery. Objective: We evaluated the protective effects of Fenofibrate (FEN) over intestinal I/R injury. Materials and methods: Intestinal I/R was induced in male Wistar rats by clamping the superior mesenteric artery for 60 minutes, followed by 60 minutes of reperfusion. Rats either received saline or FEN (100 mg/k, via gavage) daily, for three days before inducing I/R. Sham operated rats were used as normal controls. At the end of the procedure, tissue and blood samples were obtained. Serum concentrations of AST, ALT, LDH, tumor necrosis factor-alpha (TNF-alpha), malonaldehyde (MDA), and total antioxidant capacity (TAC) were determined. A histopathological analysis was also performed. Results: After I/R, there was evident tissue injury, as well as serum elevations of AST, ALT, and LDH concentrations. These alterations were reduced by FEN treatment. TNF-alpha concentrations were increased in saline treated animals when compared with FEN treated group (2.26±1 ng/ml vs. 0.23±0.41 ng/ml, respectively, p Conclusion: FEN reduced intestinal I/R injury, probably due to anti-inflammatory and antioxidant properties. Its usefulness as a treatment for I/R should be studied. Keywords: Fenofibrate, injury, intestine, ischemia/ reperfusion, rat
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.