Abstract
SummaryThe effects of fenfluramine on sympathetic nervous system activity were studied in 13 hospitalized depressed patients and in 9 obese hypertensive out-patients by measuring plasma levels of norepinephrine and dopamine-β-hydroxylase. Measurements were made in the depressed patients before and 3 hours after oral administration of 60 mg fenfluramine or placebo, and also after chronic administration (120 mg/day for at least 10 days). The obese hypertensive patients, who had not responded adequately to hydrochlorothiazide and were treated by adding 60 mg fenfluramine/day to the regimen, had measurements taken while medication free, after 2 and 7 weeks of treatment with hydrochlorothiazide alone and after combination therapy for 2 and 5 weeks. The results showed that chronic administration of fenfluramine produced a significant decrease in plasma levels of norepinephrine and dopamine-β-hydroxylase in the depressed patients, and reversed the hydrochlorothiazide-induced increases in plasma norepinephrine le...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
