Fe/Mn multilayer nanowires as dual mode T1 -T2 magnetic resonance imaging contrast agents.

Abstract

To overcome the negative contrast limitations, and to improve the sensitivity of the magnetic resonance signals, the mesoporous silica coated Fe/Mn multilayered nanowires (NWs) were used as a T1 -T2 dual-mode contrast agents (CAs). The single component Fe and Mn NWs, and Fe/Mn multilayer NWs were synthesized by electrodeposition in the homemade anodic aluminum oxide (AAO) templates with the aperture of about 30 nm. The structural characterization and morphology of single component and multisegmented NWs was done by X-ray diffraction and transmission electron microscopy. The elemental composition of Fe/Mn multilayerd NWs was confirmed by energy-dispersive X-ray and energy-dispersive spectrometer. Vibrating sample magnetometer was used to test the magnetic properties, and 1.5 T magnetic resonance imaging (MRI) scanner was used to measure the relaxation efficiency. Importantly, the MRI study indicated that the Fe/Mn multilayer NWs showed a significant T1 -T2 imaging effect, and have longitudinal relaxivity (r1 ) value, that is, 1.25 ± 0.0329 × 10-4 μM-1 s-1 and transverse relaxivity (r2 ), that is, 5.13 ± 0.123 × 10-4 μM-1 s-1 , which was two times of r1 value (0.654 ± 0.00899 × 10-4 μM-1 s-1 ) of Mn NWs, and r2 value (2.96 ± 0.0415 × 10-4 μM-1 s-1 ) of Fe NWs. Hence, Fe/Mn multilayer NWs have potential to be used as T1 -T2 dual-mode CAs.