Abstract
SummaryThe metabolism of dehydroepiandrosterone-7-3H, androstenedione-1,2-3H, and testosterone-1,2-3H by the preputial glands and genital skin (prepuce) was determined in genetic male pseudohermaphrodites, and in their littermate King-X Holtzman males and females. Both tissues in each of the three animals have an active Δ5-3β-hydroxysteroid oxidoreductase system capable of transforming dehydroepiandrosterone to testosterone and testosterone metabolites in a similar fashion to that of the woffian duct and genital tubercle of the fetus of this species as previously reported. The present results also indicate that the pattern of androgen metabolism in both tissues of the rat male pseudohermaphrodites has an elevated amount of 17β-hydroxylated and 3α-hydroxylated 5α-androstane products resembling that of the corresponding tissues of the female and is significantly different from that of its littermate male. Thus, it appears that there is a sex dependent difference in the pattern of androgen metabolizing enzym...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
