Abstract
SUMMARY The relationship between a virus isolated from a leopard spleen and the feline panleucopaenia syndrome was investigated. Inoculation of kittens with tissue culture fluids containing leopard virus (LV) produced a syndrome which was indistinguishable from that produced in a comparable group of kittens inoculated with feline panleucopaenia infected tissue, and immunity to cross challenge was established in each group. Susceptibility to challenge in each group was correlated with low levels of serum neutralizing antibody to leopard virus, and resistance to cross challenge with comparable increases in antibody to LV. Agents similar to leopard virus were isolated from the tissues of domestic cats naturally infected with feline panleucopaenia and evidence of a relationship between the agents was obtained by comparative serological and cytopathic studies. It is concluded that the agent isolated from the leopard spleen is similar to that involved in the feline panleucopaenia syndrome in domestic cats, and in all probability is the basic cause of the syndrome.
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