Abstract
AbstractFeline fibrosarcoma virus (FeSV) was assayed by focus formation in feline and marmoset fibroblast cultures overlaid with agar and re‐fed with fluid media. The FeSV titers were consistent from experiment to experiment and were about four times higher in feline fibroblasts than in marmoset fibroblasts in parallel assays. Clones of FeSV‐infected cells grown in soft agar, and foci of transformed cells produced by FeSV in monolayer cell cultures were both of two morphological types: round cells (r) and a loose meshwork of fusiform and round cells (fr). Thermal stability experiments indicated that the morphological differences of the foci were virus‐dependent.The titration pattern of FeSV grown in marmoset or feline cells indicated that these preparations were either competent or contained an excess of helper virus. Preliminary challenge experiments with Snyder‐Theilen FeSV grown in marmoset cells indicated that a 10‐ to 100‐fold excess of non‐transforming, interfering virus (helper virus) was present in this FeSV preparation.
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