Abstract
This study was conducted to examine the influence of dietary addition of 0.5g/Kg 1,1,1-trichloro-2,2-bis( p-chlorophenyl)ethane (DDT) on the effects of dietary copper deficiency in rats. Copper-deficient diet lowered tissue copper concentrations, elevated liver iron concentration, enlarged heart size, caused anemia, reduced plasma ceruloplasmin activity, and elevated levels of thiobarbituric acid reactive substances (TBARS, an indicator of oxidative stress), in liver, heart and intestinal mucosa. Although DDT feeding had no influence on tissue concentrations of copper and iron, it significantly suppressed the cardiac enlargement and elevation of TBARS levels in intestinal mucosa caused by copper-deficient diet, and elevated tissue levels of ascorbic acid. In addition, DDT feeding tended to reduce other variables associated with dietary copper deficiency, including the levels of blood hemoglobin and TBARS in liver and heart. DDT. These results indicate that DDT feeding reduces some effects of copper deficiency.
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