Abstract
Splenic B cells harvested 2 weeks after immunization of C57BL/6 mice with a high dose (4 × 10 9) of sheep erythrocytes (SRBC), when transferred to normal syngeneic recipients, suppressed the recipient's IgM and IgG plaque-forming cells (PFC) responses to SRBC. The generation of suppressive immune B cells was dependent on helper T cells. The immune B cells did not need cell division and protein synthesis for suppression to occur and did not release a suppressive factor. The mechanism of this immune B-cell-mediated suppression was different from that of antibody-mediated suppression. Double transfer experiments showed that suppressor T cells sensitive to low dose of cyclophosphamide (Cy) had been activated by the immune B cells in the presence of antigen in recipients.
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