Abstract
Injection of inositol 1,4,5 trisphosphate (InsP 3) into Limulus ventral photoreceptors elevates the concentration of intracellular calcium ions and as a consequence depolarizes the photoreceptor. This InsP 3-induced elevation can be inhibited by a prior injection of calcium or InsP 3 delivered 1 s earlier. Recovery from this inhibition has a half-time of between 1.5 and 5 s at 20°C. Calcium released by (InsP 3) therefore inhibits further release of calcium from InsP 3-sensitive calcium stores. This feedback inhibition may protect the calcium stores from depletion during prolonged bright illumination. Feedback inhibition, rather than periodic depletion of calcium stores, may also underlie the oscillatory bursts of InsP 3-induced calcium release that have been observed in many cell types.
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