Abstract
Objective: Andrographis paniculata is widely used in Asia for various medicinal purposes. The plant has a major bioactive chemical constituent Andrographolide, which exhibits various essential pharmacological properties. Recently, to enhance immunity against viral fevers especially dengue viral fever during monsoon season, Tamil Nadu state government has advised rural health centres to provide a tea or kashayam made from a mixture containing this plant leaf along with selected plant roots and leaves. However, there is concern among the general public population that this plant extract may have a negative impact on potency. This study is being done to investigate the toxic effects of Andrographis paniculata on fecundity and physiological properties of Drosophila melanogaster.
 Methods: The flies were treated and mated in pure and mixed form of Andrographis paniculata separately.
 Results: The results were obtained in the form of egg count, which was compared to control and the conclusion was obtained that Andrographis paniculata might affect the fecundity and at the same time, it was observed that the developmental span from an egg to an adult fly increased upon treatment in successive generations. More importantly, the effect of pure form plant on the fecundity was found to be significant, while that of the mixed form was not. On mating a treated male with an untreated female and an untreated male with a treated female when the treatment is being discontinued, it can be very well seen that there is no effect on the fecundity of the flies.
 Conclusion: Since the continuity of the treatment played a major role on the effect of fecundity, highlighting the importance of the period of treatment and the exposure time of the compound on the fly system, therefore this research suggests that the conception of tea or kashayam extracted from mixed plant content could not have the same effect as the similar concentration of pure Andrographis paniculata and it does not have any acute effect on the fecundity when being consumed over a short period of time in Drosophila melanogaster model.
Highlights
IntroductionHerbal remedies have been utilized in the majority of the human races as a source of medication [1, 2]
Since time immemorial, herbal remedies have been utilized in the majority of the human races as a source of medication [1, 2]
The results were obtained in the form of egg count, which was compared to control and the conclusion was obtained that Andrographis paniculata might affect the fecundity and at the same time, it was observed that the developmental span from an egg to an adult fly increased upon treatment in successive generations
Summary
Herbal remedies have been utilized in the majority of the human races as a source of medication [1, 2]. In most of the developing countries, majority people depend on traditional practitioners, who in turn are dependent on medicinal plants, to meet their primary healthcare needs [3, 5, 6] In both underdeveloped and developed countries plant-based medicines still play an important role in the primary healthcare because of their reduced side effects and their availability in the nature [3, 10, 30]. Development of restorative plants with research facility produced species is being endeavoured based on concoction creation and is probably going to be utilized as a part of the expanded way for a business reason These progressions may have a significant effect on the wellbeing and viability of the Ayurveda medicines in the market
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