Abstract
Clostridium difficile infection (CDI) is an emerging problem in terms of incidence, morbidity and mortality. Currently available treatment options are not always effective, especially in cases of recurrent/refractory or complicated CDI. The gut microbiota transplantation is a technique that has been sporadically practiced since the ‘50s, but its clinical efficacy has only recently been supported by scientific evidence. In the present article, we report the pathophysiological basis and the clinical indications of this technique that, in light of its low cost, and proven efficacy and safety, is likely to become part of the management guidelines of difficult cases of CDI in the near future.
Highlights
Over the last few years, the term intestinal flora has been gradually replaced with that of gut microbiota, indicating the growing awareness of the existence of an actual organ responsible of multiple physiological functions, to what has happened with the adipose tissue in metabolic diseases
We report ia the pathophysiological basis and the clinical indications of this technique that, in light of rc its low cost, and proven efficacy and safety, is likely to become part of the management e guidelines of difficult cases of Clostridium difficile infection (CDI) in the near m future
Clinical use of the intestinal microbiota transplantation: scientific evidence om Introduction -c The epidemiology of Clostridium difficile n infection (CDI) is pointing towards a signifio cant increase in morbidity and mortality rates, N especially in developed countries
Summary
The ideal recipient candidates are patients older than 18 years with recurrent CDI and failure to at least one cycle of appropriate antibiotic therapy. The number of recurrent episodes necessary to include the patient is will be likely reviewed in the future, especially if the fecal transplant is proposed as an alternative to colectomy in fulminant cases. Patients with low life expectancy are usually excluded.[8,11]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
