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Abstract
Infectious diarrhea takes a leading position in all infectious diseases worldwide. As a result of the pathogens diversity, patient-specific diagnosis and treatments are needed. Additional laboratory tests are crucial for differentiation among pathogens, as routine bacteriological and virological methods are time-consuming. One of them is fecal calprotectin. Aim: examination of the potential role of fecal calprotectin in infectious diarrhea. Materials and methods: the national and international medical literature sources were analyzed. Results: the data regarding fecal calprotectins’ structure, functional activity and diagnostic value are presented. Conclusions: the study of fecal calprotectin, as a correlative biomarker of bacterial gastroenteritis, can be helpful for clinicians with diagnostic approach to the patient.
Highlights
Infectious diarrhea takes a leading position in all infectious diseases worldwide
Согласно Консенсусу Болгарского общества по инфекционным болезням, диарея представляет клинический симптом, при котором наблюдаются 3 или более дефекации за 24 ч фекальными массами, изменёнными в цвете, количестве или консистенции с или без наличия патологических примесей
Correlation between fecal calprotectin levels, disease severity and the hypervirulent ribotype 027 strain in patients with Clostridium difficile infection
Summary
Infectious diarrhea takes a leading position in all infectious diseases worldwide. As a result of the pathogens diversity, patient-specific diagnosis and treatments are needed. Бактерии и паразиты как возбудители доминируют в развивающихся странах и нередко являются причиной развития «хронической» персистирующей диареи[6]. Конкурентное комплексообразование с металлами лежит в основе антимикробного эффекта кальпротектина, так как марганец и цинк выступают как кофакторы в бактериальных антиоксидантных ферментах, позволяющих микроорганизмам противодействовать нейтрофильному оксидативному стрессу в процессе интестинального воспаления [12, 13] и, соответственно, имеют жизненно важное значение для бактериального роста и развития
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