Abstract
One of the most controversial issues in epilepsy research is whether prolonged febrile seizures cause mesial temporal sclerosis (MTS) and temporal lobe epilepsy (TLE). Retrospective studies from tertiary epilepsy centers report that many adults with intractable TLE have a history of prolonged or atypical febrile seizures in childhood. However, population-based studies have failed to confirm this association, as have prospective studies of febrile seizures (1). This review summarizes the current knowledge from epidemiologic, imaging, and animal studies regarding this controversial subject, and it attempts to define the issues that should be addressed in future research.
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