Features of tissue doppler ultrasonography in patients with viral liver cirrhosis

Abstract

Aim. To study the influence of pulmonary hypertension, viral load, and presence of ascites on indicators of longitudinal global and segmental systolic and diastolic ventricular functions in patients with liver cirrhosis as an outcome of viral hepatitides. Methods. The study included 75 patients with liver cirrhosis class A, В, C by Child-Pugh as an outcome of viral hepatitides who were distributed into 3 groups depending on the presence of pulmonary hypertension, ascites, and of viral load. All patients underwent Doppler echocardiography and tissue Doppler echocardiography. Results. Decreased global longitudinal systolic and diastolic function of the left and right ventricles was revealed in patients with virus-related liver cirrhosis, which decreased in the presence of pulmonary hypertension, moderate viral load and ascites. While studying an association between the structural and functional heart indices and hepatic and portal blood flow, it was found that average mitral and tricuspid valve peak systolic velocity was associated with left ventricle ejection fraction (r=0.71, p 0.05), liver veins diameter and blood flow speed parameters (r=0.32-0.81, p 0.05), pulmonary artery pressure (r=0.37-0.84, p 0.05), and viral load (r=0.92, p 0.05). Conclusion. Patients with virus-related liver cirrhosis have decreased global longitudinal systolic and diastolic function of the left and right ventricles, deteriorated by pulmonary hypertension, ascites, and moderate viral load.