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Abstract
The aim of this study was to study the eff ects of using the infusion drug Remaxol in young patients with alcoholic liver disease.Materials and methods: the clinical and laboratory data of 80 young patients with alcoholic liver disease were analyzed, divided depending on the treatment regimen into 2 groups: the main (n = 44) who received Remaxol according to the scheme: 400 ml iv, drip, at a rate 40–60 drops per minute daily, course No. 5–10, and control (n = 36) — received basic therapy. In all patients, the dynamics in blood serum was studied: lipid peroxidation indices (malondialdehyde, diene conjugates), antioxidant protection enzymes (catalase, SOD, glutathione peroxidase), markers of cytolysis, cholestasis and lipid metabolism.Results: initially there was a significant increase in lipid peroxidation processes, accompanied by slight stimulation of the antioxidant system of the liver and pronounced signs of cytolysis and cholestasis. The inclusion of Remaxol in treatment regimens leads to a significant decrease in the level of malondialdehyde and diene conjugates, and the restoration of the antioxidant system (increase in catalase, SOD, and glutathione peroxidase). At the same time, a marked decrease in the syndromes of cytolysis and cholestasis was noted, which was accompanied by an improvement in the condition of the patients: cessation of nausea, restoration of appetite and sleep, and improvement of well-being.
Highlights
Results: initially there was a significant increase in lipid peroxidation processes, accompanied by slight stimulation of the antioxidant system of the liver and pronounced signs of cytolysis and cholestasis
The aim of this study was to study the effects of using the infusion drug Remaxol in young patients
who received Remaxol according to the scheme
Summary
Н. Особенности терапии алкогольной болезни печени у лиц молодого возраста. Мязин Роман Геннадиевич, кафедра пропедевтики внутренних болезней, к.м.н., доцент Емельянов Дмитрий Николаевич, кафедра пропедевтики внутренних болезней, к.м.н., доцент, заведующий кафедрой. Emel’yanov, department of propaedeutics of internal medicine, cand. (med.), assistant professor, head of department; ORCID ID: https://orcid.org/0000–0003–0716–9020. Целью настоящего исследования явилось изучение эффектов использования инфузионного препарата Ремаксол у пациентов молодого возраста с алкогольной болезнью печени. Материалы и методы: проанализированы клинико-лабораторные данные 80 пациентов молодого возраста с алкогольной болезнью печени, разделенные в зависимости от схемы терапии на 2 группы: основную (n=44), получивших Ремаксол по схеме: 400 мл в/в, капельно, со скоростью 40–60 капель в минуту ежедневно, курс No 5–10, и контрольную (n=36) — получивших базисную терапию. Ключевые слова: алкогольная болезнь печени, диагностика, перекисное окисление липидов, антиоксидантная система, цитолиз, холестаз, лечение, Ремаксол
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