Abstract
Flavonoids and their derivatives have historically been a source of therapeutic agents. Every year, more and more data is published on new flavonoid compounds, both synthetic and isolated from natural sources, and their innumerable physiological and pharmacological activities. This review presents synthetic routes towards 3-(carboxyphenyl)chromones and evaluation of their biological activity as published in both journal and patent literature. We have focused specifically on the 3-(carboxyphenyl)chromones, because while methods of synthesis and biological activity of 2(3)-substituted and 2,3-disubstituted chromones are well studied, literature data on isoflavones containing a carboxyl, ester, or amide group in ring B is scarce and fragmentary. The presented generalization of synthetic strategies and biological activity of 3-(carboxyphenyl)chromone derivatives demonstrates that this class of compounds can be targeted for discovery of new drugs and can be readily prepared owing to recent advances in synthetic organic and medicinal chemistry.
Highlights
Flavonoids and their derivatives have historically been a source of therapeutic agents
The majority of research activity in recent years has been focused on the synthesis of 2(3)-substituted and 2,3-disubstituted chromones [1,2,3,4,5,6,7]
Among numerous currently known isoflavone derivatives, compounds 1 with a carboxyl group in the ring B constitute a small group of compounds (Figure 1)
Summary
Flavonoids and their derivatives have historically been a source of therapeutic agents. Despite the obvious prospect, studies of synthesis of isoflavones containing a carboxyl, ester, or amide group in the B-ring have received little attention.
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