Features of the skin microbiota in patients with diabetes

Abstract

The assessment of the skin microbiota state in elderly people with diabetes mellitus is given. For the research and development of quantitative and specific indicators of deep microbiota of the skin used the method of agar imprints. The revealed changes in the skin microbiota in patients with diabetes mellitus are of interest as adaptive characteristics of the organism, and also serve as a harbinger of deviations in the clinical and physiological status of patients and give reason to present the basic laws of skin biocenosis in elderly people suffering from diabetes mellitus. It was found that the species composition of the microbiota does not change in the control group in the deep layers of the forearm skin, and the number of colony-forming units increased, which corresponds to skin dysbiosis of the I degree. It was also found that representatives of Staphylococcus spp occupy a dominant position in the skin microbiota in persons with diabetes mellitus, both in frequency of occurrence and in quantitative measure. At the same time, in the observed patients, regardless of the type and stage of diabetes mellitus, an increase in the number of colony-forming units by 1 cm2 of the deep layers of the forearm skin was revealed, which corresponds to the dysbacteriosis of the skin of the III degree. This is 2,6 times greater than in healthy individuals. This increase is directly correlated with the severity of diabetes. It is shown that dysbiosis can manifest itself by clinical local symptoms, and then by General disorders, which aggravate the course of the underlying disease and complicate treatment. An integrated approach to this problem can be used for a more differentiated assessment of the prognosis of complications in patients with diabetes mellitus and to improve the effectiveness of treatment and preventive care.