Features of the reparative process after glaucoma surgery (an experimental study)

Abstract

The characteristic features of the wound process in the ocular tissues and the effects of drugs that directly affect the formation of connective tissue in the area of intervention are important for understanding and evaluating the prognosis of glaucoma surgery. This experimental study consisted of imitating a glaucoma surgery and evaluating the therapeutic effect of drugs affecting the reparative processes. When assessing the degree of hyperemia in the area of formed filtration blebs as the main prognostic sign of excessive scarring in the postoperative period, its maximum severity was noted with a low tendency to decrease throughout almost the entire follow-up period in the group with the introduction of 5-fluorouracil (5-FU). Morphologically, as the inflammatory process subsided, an increase in the density of fibroblasts was detected in the surgery site, indicating a presence of an active proliferative process. The least amount of local tissue reaction to surgical trauma was noted in the group with 5-FU drug injected in the filtering bleb area in the postoperative period: the absence of inflammatory cells in the stroma, expansion of episcleral vessels and low density of connective tissue cells in the area of surgically formed intraocular fluid outflow pathways. The obtained experimental data indicates a decrease in the activity of scarring processes in the glaucoma surgery site and, consequently, a favorable prognosis of its longterm effectiveness.