Features of the relationship between cone-beam computed tomography and the severity of oxidative stress in chronic generalized periodontitis with and without bronchoectatic disease

Abstract

The study identified and analyzed the relationship between cone-beam computed tomography (CBCT) and markers of oxidative stress in patients with chronic generalized periodontitis (CGP) without somatic pathology and with bronchoectatic disease. 90 patients with CGP were examined, which were divided into two groups: patients with CGP without somatic pathology (n=40) and patients with CGP with comorbid pathology in the form of bronchiectatic disease (n=50). Somatically healthy persons with intact periodontal disease (n=40) were examined as a control group. Enzyme immunoassay was used to determine the levels of malondialdehyde (MDA), advanced oxidation protein products (AOPP) and total superoxide dismutase (total SOD) of all three types — Cu/Zn-SOD + Mn-SOD + Fe-SOD) in oral fluid. In patients with CGP observed intensification of oxidative stress expressed in an increase in oxidation products of lipids and proteins, as well as a decrease in antioxidant protection. Greater intensification of the process of oxidative stress and deeper changes in periodontal tissues were detected in patients with CGP with bronchiectatic disease. According to the results of correlation analysis, statistically significant, positive relationships of different strength between changes in the level of MDA, AOPP, total SOD and CBCT parameters in patients with CGP, both without somatic pathology, and with bronchiectatic disease were revealed. The revealed interrelations evidence of the influence of the intensification of the process of oxidative stress on a condition of periodontal tissues at patients with CGP. The strength of the identified relationships between most of the indicators characterizing CB CT deep periodontal lesions was greater in patients with CGP with bronchiectatic disease.