Abstract
We have examined 36 liquidators (participants in emergency clean-up after the Chernobylnuclear accident) many years after the external γ-irradiation (on average (143.0 ± 14.0) mGy for (3.3 ± 0.8) months) and 13 workers of a typical research nuclear reactor, who were subject to chronic external γ-irradiation (on average (78.40 ± 12.21) mGy for (13.1 ± 2.2) years). The level of metabolites of lipid peroxidation (conjugated diene and triene conjugates of lipid hydroperoxides, TBA-reactive products) and the activity of catalase, superoxide dismutase, 5'-nucleotidase in blood serum were determined; changes in vessels of microcirculatory bloodstream (MCB) in skin-muscle bioptate were analyzed. Under the action of small doses of ionizing radiation, the oxidative disbalance and changes in activity of 5'-nucleotidase in blood serum сaccompanying the systematic inflammatory alteration of MCB vessels were found.
Highlights
Features of the oxidation processes and state of microcirculatory channel have persons exposed to low doses of ionizing radiation
We have examined 36 liquidators many years after the external γ-irradiation (on average (143.0 14.0) mGy for (3.3 0.8) months) and 13 workers of a typical research nuclear reactor, who were subject to chronic external γ-irradiation (on average (78.40 12.21) mGy for (13.1 2.2) years)
В группе ликвидаторов последствий аварии (ЛПА) на Чернобыльской АЭС (ЧАЭС) реже относительно пациентов группы сравнения и лиц контрольной группы выявлялись сосуды без изменений — у 4 (11,1%) против 13 (16,9%, χ2 = 14,01; р = 0,0002) и 9 (81,8%, χ2 = 17,67; р < 0,0001) соответственно; чаще регистрировался панваскулит выраженной степени — у 24 (66,7%) против 1 (4,8%, χ2 = 18,20; р < 0,0001) и 0 (0%, χ2 = 12,44; р = 0,0004) соответственно — при отсутствии различий в частоте пролиферативной васкулопатии и продуктивного васкулита минимальной степени
Summary
Features of the oxidation processes and state of microcirculatory channel have persons exposed to low doses of ionizing radiation. Цель работы — оценить морфологическое состояние сосудов МЦР в кожно-мышечном биоптате, содержание продуктов ПОЛ, активность антиоксидантных ферментов и 5'НТ в сыворотке крови у ликвидаторов последствий аварии на ЧАЭС и профессиональных работников ядерного реактора.
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