Abstract
Objective: Study specific Igg4 antibodies to milk proteins indexes in healthy babies living in different Russian megalopolises.Methods: The complex research of the specific Igg4 antibodies to milk proteins during cohort study of 259 healthy babies of the first year of life. Children lived in five Russian cities: 60 children in Moscow, 50 newborns – in Saint Petersburg, 55 children came from Kazan, 43 children lived in Khabarovsk and 51 – in Vladivostok. Non-competitive enzyme-linked immunosorbent assay was used to quantify specific Igg4 antibodies to cow milk proteins (CMP), beta-lactoglobulin (β-LG), alpha-lactalbumin (α-LA), casein and goat's milk protein (GM) in coprofiltratesResults: The highest frequency of the high Igg4 was discovered to CMP and goats’ milk was observed among children from Saint Petersburg during comparative assessment of the frequency of defining Igg4 to milk proteins in healthy newborns aged 2.5 months living in Moscow and Saint-Petersburg. The highest frequency of Igg4 increased rates to milk proteins among newborns from Kazan, Khabarovsk and Vladivostok was diagnosed during first three months of life on breastfeeding without any clinical symptoms of food intolerance. With age decrease of the frequency of specific Igg4 to milk proteins were observed among all babies from above-mentioned cities. By 8 month of life it made isolated cases.Conclusions: High frequency of increased Igg4 to milk proteins among 2 months old babies on breastfeeding was observed in the cities of Central and Far Eastern districts of Russian Federation. In this regard it can be supposed that Igg4s were got from mothers in the prenatal period and after birth through breastfeed. The presence of high frequency of the increased indexes of specific Igg4 to milk proteins probably was related to mothers’ nutrition habits during pregnancy and lactation periods.
Highlights
High frequency of increased Igg4 to milk proteins among 2 months old babies on breastfeeding was observed in the cities of Central and Far Eastern districts of Russian Federation. In this regard it can be supposed that Igg4s were got from mothers in the prenatal period and after birth through breastfeed
Наличие повышенных IgG4 к молочным белкам у наблюдаемых здоровых детей, вероятно, было связано с характером питания матерей, как во время беременности, так и в период
Summary
Особенности формирования специфических IgG4-антител к молочным белкам у здоровых детей раннего возраста, проживающих в разных мегаполисах РФ. Цель: изучение показателей специфических IgG4-антител к молочным белкам у здоровых детей раннего возраста, проживающих в разных мегаполисах РФ. При когортном исследовании 259 здоровых детей первого года жизни проводилось комплексное изучение специфических IgG4 к молочным белкам. При сравнительной оценке частоты обнаружения IgG4 к молочным белкам у здоровых младенцев в возрасте 2,5 месяцев жизни из Москвы и Санкт-Петербурга наибольшая частота высоких IgG4 была обнаружена к БКМ и козьему молоку у детей из Санкт-Петербурга. Для цитирования: Денисова С.Н., Тарасова О.В., Ни А., Ревякина В.А., Ильенко Л.И., Сахарова Е.С.
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