Features of the cytotoxic effect of lymphocytes with cardiolipin in patients with ischemic stroke in low mountain area

Abstract

Sensitization to phospholipids can act not only as an immediate cause of development of the ischemic stroke (IS) itself, but as its complications also, which, in combination with other factors may aggravate the course of the disease. One of the rarely used methods that reflect the state of lymphocyte sensitization and tendency to thrombus formation is the study of the reaction of the cytotoxic effect of lymphocytes to cardiolipin (CESL) Recognition of the concept of pathogenetic heterogeneity of ischemic cerebral blood circulation is of great practical importance, since only upon revealing the cause and pathogenetic mechanism of the development of an acute cerebrovascular episode, it becomes possible to conduct adequate therapy and secondary prevention We examined 36 patients with diagnosis of IS on 1st and 10th day since onset of the disease. The average age 64.50±10.88.The diagnosis was verified by clinical examinations, including hemostasiological screening studies. CESL was determined by the standard method. The higher rates of CESL in the examined patients were observed on the background of hypercoagulable changes in the blood. Since sensitization to cardiolipin contributes to an increased tendency to thrombus formation, our data can reflect this process in severe acute and acute stage of ischemic stroke. In patients with ischemic stroke, autoimmune reactions of lymphocytes to cardiolipin are detected. The apparency of cytotoxic reactions of lymphocytes to cardiolipin depends on the severity of the process. The CESL for cardiolipin may serve as an additional criterion for the presence of hemostasiological disorders in patients with cerebral infarctions.