Features of the current of bronchial asthma in the presence of komorbidy allergic rhinitis

Abstract

Aim - study of the influence of komorbidy allergic rhinitis (AR) on the course of bronchial asthma (BA). Clinical research, single performed by a survey of 96 patients divided into two groups: the main - 73 patients with BA combined with AR and a group of comparison-23 patients who do not have allergic rhinitis. The data of clinic, bronchial passableness, level of control of asthma, severity of inflammation in bronhopulmonary region on content of nitrogen oxide in exhaled air and in nasal flushes of a number of biochemicals were studied in comparative aspect. Indicators, the manifestation of systemic inflammatory response according to biochemical, immunological indicators and calculated lejkocitarnym indices. It is revealed that activity of inflammatory process in patients with BA without AR is higher both in the bronhopulmonary region and at the system level. At the same time in the period of clinical remission, most of them have sufficiently well functioning protective mechanisms on the part of the antioxidant system, humoral immunity, non-specific protection. When combined BA and AR inflammation at both local and system levels is less pronounced, but the activity of protective mechanisms decreases. In parallel to the growth of violations on the part of cell and humoralal links of immunity in the blood increases the content of Circulating immune complexes, which contributes to the torpor current of inflammation, which is the basis of a more significant violation of bronchial permeability and complicates achieve control of asthma. These changes increase as the duration of the disease both BA and AR, as well as frequency exacerbations of the disease.