Features of the course of the gestational process with the carriage of genotypes F5L:G(1961)A and F2:G(20210)A and inheritance options

M G Nikolaeva,L A Strozenko,N N Yasafova,A P Momot

doi:10.21682/2311-1267-2021-8-3-50-58

M G Nikolaeva, L A Strozenko + Show 2 more

Open Access

https://doi.org/10.21682/2311-1267-2021-8-3-50-58

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Abstract

Aim of the study – to establish the features of inheritance of the F5L:G(1961)A and F2:G(20210)A genotypes and to assess their influence on the course and outcomes of pregnancy.Materials and methods. The object of the study was 70 mother–child pairs: 50 women, carriers of the F5L:G(1961)A mutation, and their children; 20 female patients, carriers of the F2:G(20210)A mutation, their children. Additionally, 18 families of women, carriers of the factor V Leiden mutation, in three generations were studied.Results. Carriage of the F5:(1961)GA and F2:(20210)GA genotypes in fetuses is associated with the risk of developing gestational complications in their mothers, which are primarily realized when the maternal laboratory phenotype is manifested. A higher frequency of occurrence of the minor allele A20210 of the FII gene was determined in children than in the older generation (p = 0,0006).

Highlights

Features of the course of the gestational process with the carriage of genotypes F5L:G(1961)A and F2:G(20210)A and inheritance options
Carriage of the F5:(1961)GA and F2:(20210)GA genotypes in fetuses is associated with the risk of developing gestational complications in their mothers, which are primarily realized when the maternal laboratory phenotype is manifested
A higher frequency of occurrence of the minor allele A20210 of the FII gene was determined in children than in the older generation (p = 0,0006)

Summary

Анализируемый параметр Analyzed parameter

Возраст пациентки на момент беременности Patient’s age at the time of pregnancy Соматическая патология Somatic pathology гипертоническая болезнь hypertension Варикозная болезнь нижних конечностей Varicose veins of the lower extremities Тромботические события в личном анамнезе Personal history of thrombotic events Избыточная масса тела (индекс массы тела 25) Overweight (body mass index 25) Течение анализируемой беременности The course of the analyzed pregnancy Благоприятное течение Favorable course Осложнения гестации Complications of gestation тяжелая ПЭ severe preeclampsia ЗРП fetal growth restriction ПОНРП premature detachment of the placenta.

Частота аллеля Allele frequency

Полиморфизм Генотипы Polymorphism Genotypes

Premature detachment течение of the placenta