FEATURES OF THE COURSE OF IDIOPATHIC HYPERCALCIURIA IN CHILDREN. ANALYSIS OF CLINICAL AND LABORATORY MANIFESTATIONS

Abstract

THE AIM: to study clinical and laboratory manifestations of hypercalciuria in children of Barnaul, living in the zone of sharply continental climate of the South of Western Siberia. PATIENTS AND METHODS. The study included 239 children aged from 1 month to 16 years (mean age of 6.6±2,72 years) with idiopathic hypercalciuria (IH), diagnosed according to the level of calcium/creatininemia coefficient (CCC), more than 0.6 mmol/mmol and normal plasma calcium and parathyroid hormone. Conducted physical examination and biochemical blood and urine determination of calcium, phosphorus, creatinine, urea and uric acid, ultrasound of the kidneys and bladder, radiopaque research methods indicated. RESULTS. Family history of urolithiasis have been reported in 56.1% children with hypercalciuria. Analysis of comorbidity showed a combination of IH with urolithiasis in 15.1% patients with urinary system infections(USI) – in 38.5%, with anomalies of the urinary system – 27,2% children with neurogenic disorders of urination – at 9.2 percent. The clinical picture of the disease prevailed dysuric disorders (48,5%) and moderately pronounced edema syndrome (45,6%). In the urinary sediment of children with hypercalciuria, the most frequently recorded crystalluria (31,8%), microhematuria (19,2%) and leukocyturia (13.8%). CONCLUSION. Idiopathic hypercalciuria in children is often combined with such pathological conditions as USI, neurogenic disorders of urination, abnormalities of the urinary system and it is the cause of the development of the urolithiasis already in childhood.