Features of the course of bronchial asthma in children with a history of bronchopulmonary dysplasia

Abstract

Introduction. The development of bronchial asthma in children is often associated with previous bronchopulmonary dysplasia. Objective . To study the features of the clinical course of bronchial asthma in children with a history of bronchopulmonary dysplasia. Children characteristics and research methods . The test group consisted of 77 patients with a history of bronchial asthma and bronchopulmonary dysplasia. The control group included 81 patients with bronchial asthma without bronchopulmonary dysplasia. The patients were diagnosed in accordance with the Classification of clinical forms of bronchopulmonary diseases in children. The level of immunoglobulins was determined by enzyme immunoassay. Results. The patients with bronchial asthma and bronchopulmonary dysplasia demonstrated an earlier manifestation of bronchial asthma, a mild course and a rare need for inhaled bronchodilators, significant disproportions in changing the level and frequency of allergic inflammation markers — frequent eosinophilia with a lower increase in total IgE. The developed stage-by-stage program of examination and management of children with bronchial asthma and bronchopulmonary dysplasia will improve the diagnosis and treatment of patients with these diseases. Conclusion. The pediatricians shall take into account the identified clinical features of bronchial asthma in children with a history of bronchopulmonary dysplasia in their practice.