Abstract
To study the specific features of the pathogenesis of urticaria and to clarify the mechanisms maintaining its chronic course, complement components (C3a, C4, and C1‑inhibitor (C1inh)) were examined in the blood of 50 children with chronic urticaria and 15 healthy children without manifestations of allergy and pseudoallergy. The magnitude of disorders of the complement system was estimated in relation to age, disease duration, and the presence of comorbidity. The serum concentrations of С3а, С4, and С1inh were determined by enzyme immunoassay. Children with an exacerbation of chronic urticaria were established to have elevated C3a and C1inh levels. Decreased C4 levels were associated with autoimmune urticaria and observed in children with a disease duration of more than a year. The levels of C1inh and C4 exhibited a negative paired correlation detected in most children with a positive autoserum test.
Highlights
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia; A
The magnitude of disorders of the complement system was estimated in relation to age, disease duration, and the presence of comorbidity
The serum concentrations of С3а, С4, and С1inh were determined by enzyme immunoassay
Summary
Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia; A. С целью изучения особенностей патогенеза и уточнения механизмов, поддерживающих хроническое течение крапивницы, были исследованы компоненты системы комплемента (С3а, С4, С1-ингибитора — С1inh) в крови 50 детей c хронической крапивницей и 15 здоровых детей без проявлений аллергии и псевдоаллергии. Особенности системы комплемента у детей с хронической крапивницей являются основным звеном патогенеза крапивницы [6]. Исследование концентраций таких компонентов, как С3а, С4 и С1 ингибитор (С1inh), необходимо для выявления патологии системы комплемента при ангиоотеках, уртикарном васкулите и других аутоиммунных заболеваниях, иммунодефицитных состояниях и рецидивирующих бактериальных инфекциях [7, 8]. В связи с гетерогенным характером хронической крапивницы и возможным наличием генетически детерменированных поломок в системе комплемента, влекущих за собой рецидивирование уртикарных высыпаний, ангиоотеков, показано определение концентрации С3а, С4 и C1inh в сыворотке крови пациентов с хронической крапивницей. Цель исследования: изучить особенности активации компонентов комплемента (C1inh, C4, C3a) при хроническом течении крапивницы
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