Abstract
The purpose of the study: to establish the features of the of colon cavity (CC) microbial state in patients with non-alcoholic steatohepatitis (NASH) with obesity, depending on the presence of comorbid chronic kidney disease (CKD) and its stages. Material and methods of research. 168 patients with NASH from 42 to 55 years of age were examined. All patients were distributed as follows. Group 1 consisted of 68 patients with NASH and obesity of 1st degree. Group 2 consisted of 100 patients with NASH and obesity of 1st degree with a comorbid CKD I-III stages (chronic pyelonephritis). We examined 30 practically healthy persons (PHPs), which by age and sex were not statistically significantly different from the main group and the comparison group. Microbiocenosis of CC was studied by microbiological method by sowing ten-fold dilutions of feces on differential-diagnostic nutrient media in accordance with the methodological recommendations Microbiological diagnosis of of the Ministry of Health of the USSR (1986).Results of the research and their discussion. The study revealed changes in the microbial cavity content of the colon (CC) during the comorbid flow of NASH with obesity and the CKD I-III stages, characterized by the development of deep dysbiosis (II-III degree) With the appearance and prevalence of pathogenic microflora, an increase in the number of opportunistic bacteria and yeast fungi of the genus Candida, a probable deficiency of representatives of normal microbiota: lactobacilli, bifidobacteria, bacteroids.Conclusion. It is established that one of the components of the pathogenesis of non-alcoholic steatohepatitis in patients with obesity and chronic kidney disease is metabolic intoxication, which arises as a result of a significant violation of the quantitative and qualitative composition of the microflora of the microbial cavity of the colon with the development of deep dysbiosis.
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