FEATURES OF THE BIOCENOSIS OF TROPHIC ULCERS ON THE BACKGROUND OF CHRONIC VENOUS INSUFFICIENCY, THE POSSIBILITY OF TREATMENT

Abstract

Introduction. The reasons for long-term healing of TU of the lower extremities are bacterial contamination of ulcers with the formation of biofilms.
 The urgency of the problem. The frequency of TU of the lower extremities, microbial resistance and a significant frequency of relapses (20–70 %) determines and justifies the urgency of the problem.
 Goal. To study the features of the TU biocenosis of the lower extremities and the possibility of treatment without the use of antibiotics.
 Materials and methods. Patients with TU were divided into two groups. The first (main) group (n = 57) included patients who received apatite polymer drainage bandage, the second group (comparison) consisted of patients treated with traditional methods (n = 53). Smears from the wound surface of the TU were examined for sensitivity to APDB.
 Results and discussion. The intensity of microbial contamination of TU before treatment was 106CFU / ml, on the 3rd day after application of APDB — 104 CFU/ml, on the 5th day — 103 CFU/ml. The average rate of wound healing was 0.42 cm2/day of the wound surface area.
 Conclusions. 1. Staphylococcus ssp dominates in microbiocinosis TU — 52.7 %, E. coli — 34.6 %. 2. The use of APDB without the use of antibiotics reduces microbial contamination. 3. The average duration of treatment in the main group was 19.6 days in the comparison group — 28.2 days.