Abstract

Spleen is the biggest peripheral immune organ. As the place where mature lymphocytes aggregated,the integrate architecture of splenic white pulp is the structural foundation for prompt and effective response of immune system. It includes distinct T/B segregation and marginal zone,existence of follicular dendritic cells network and germinal centers. Continuing researches on the mechanisms involved in the maintenance of the architecture in splenic white pulp will provide rationale for the prevention and treatment of the relating diseases. Key words: Spleen; Lymphoid follicle; Germinal center

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