Abstract
Lymphoblastic lymphoma (LBL) is a rapidly progressive, malignant disease from T and B progenitor cells. Lymphomas from T cell precursors (T-LBL) account for up to 80% of all LBLs. Despite the rather rare occurrence of T-LBL, the relapsing and refractory course of this disease is an actual problem. Programs for the treatment of relapses and refractory forms of T-LBL are currently being actively developing. The role and place of targeted drugs in the multimodal T-LBL relapse strategy is determined. Further fundamental research is aimed at overcoming drug resistance, studying the molecular genetic mechanisms, tumor cell signaling pathways, which will improve treatment outcomes and survival. Based on clinical case the authors will be considered clinical features of relapses and refractory form of T-LBL and possible methods of treatment. Parents gave their consent to use information about the child, including fotos, in the article.
Highlights
ФГБУ «Национальный медицинский исследовательский центр детской гематологии, онкологии и иммунологии им
Lymphomas from T cell precursors (T-Lymphoblastic lymphoma (LBL)) account for up to 80% of all LBLs
Further fundamental research is aimed at overcoming drug resistance, studying the molecular genetic mechanisms, tumor cell signaling pathways, which will improve treatment outcomes and survival
Summary
Особенности течения рецидивов и рефрактерных форм Т-лимфобластной лимфомы у детей. Контактная информация: Абашидзе Залина Ахмедовна, врач-гематолог боксированного отделения гематологии/онкологии ФГБУ «НМИЦ ДГОИ им. В статье на примере клинического случая рассмотрены особенности течения рецидивов и рефрактерных форм Т-ЛБЛ у детей, а также возможные методы терапии. Features of relapses and refractory forms of T-lymphoblastic lymphoma in children. Based on clinical case the authors will be considered clinical features of relapses and refractory form of T-LBL and possible methods of treatment. Parents gave their consent to use information about the child, including fotos, in the article. В данной статье рассмотрены особенности течения рецидивов и рефрактерных форм Т-ЛБЛ у детей, а также возможные методы терапии на примере клинического случая
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