Features of regional blood flow in young people with vitamin B<sub>12</sub> deficiency anemia

Abstract

Aim. To investigate specific features of regional blood flow in the liver of young people with vitamin B12 deficiency anemia (VBDA).Materials and methods. A total of 64 patients diagnosed with VBDA with the median age of 38 years and 95% confidence interval [26; 49] were examined. Hemodynamic parameters of the liver and central circulation were assessed using pulsedwave Doppler ultrasound with color and power imaging. Statistical data was processed by Statistica 25.0.Results. At the onset of VBDA, the revealed hemodynamic disorders are primarily associated with a 13.8% decrease in the ratio of the linear velocity of the portal flow and the diameter of the portal vein, which leads to liver blood stagnation. A long medical history of VBDA is associated with the venous collector of hepatic hemodynamics and a decrease in the volume values (16.8%) against the background of increased peripheral vascular tone of hepatic vessels (23.5%). A correlation between the indicators of regional blood flow in the liver and the type of central hemodynamics was revealed, being most pronounced in severe VBDA and the hypokinetic hemodynamics type.Conclusion. Assessment of the regional blood flow of the liver was found to be an effective method for diagnosing the state of target organs in VBDA and for verifying the predictors of VBDA severity.