Abstract
Changes in the specific liver mass, number of single and binucleate cells of different ploidy, mitotic index and alteration index, DNA content and inclusion of 3H-thymidine in DNA of Wistar rats and CBA mice in the following conditions: at 0°C for 3, 7, 14 days for 23 hours per day, and in the highlands conditions (3, 200 m above sea level) for 3 and 30 days. Activation of regenerative processes has been established — proliferation of hepatocytes (mainly diploid) in combination with polyploid cell share reduction, as well as cellular hypertrophy development. Cell dynamics shifts persisted throughout the observation duration and were opposite in direction when growing up and aging.
Highlights
Body effects of various adverse and especially extreme factors are usually associated with tissue changes perceived to be directly or indirectly related to the functional system aging process and the limitation of its resource
It is undeniable that the action of external factors triggers multicomplex adaptation mechanisms; sustainable adaptation is impossible without the structural adaptation footprint, the formation of which is provided by regenerative processes in the modern understanding of their essence
The effect of extreme factors on the regenerative processes themselves and the mechanisms of such influence are not fully studied [3,4,5,6]. It is the state of regenerative processes that can determine the adaptation mechanisms to the factors of the external environment, and possible irreversible alterations - the essence of one of the sides of the organism aging
Summary
Body effects of various adverse and especially extreme factors are usually associated with tissue changes perceived to be directly or indirectly related to the functional system aging process and the limitation of its resource. The effect of extreme factors on the regenerative processes themselves and the mechanisms of such influence are not fully studied [3,4,5,6]. It is the state of regenerative processes that can determine the adaptation mechanisms to the factors of the external environment, and possible irreversible alterations - the essence of one of the sides of the organism aging. The purpose of this work was to investigate the features of adaptive growth, i.e. the state of regenerative processes in the liver without additional induction under the influence of cooling and in the highland conditions. The choice for liver research is dictated by the organ's important role in ensuring the organism resistance involved in any effects on the organism, as well as the peculiarities of regenerative processes — low proliferative activity, pronounced cell polyploidy, intensive regenerative response to damage
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