FEATURES OF PRE-GRADUATION TRAINING OF FUTURE PARENTS AFTER THE EXPERIENCED DISEASE OF COVID–19.

Abstract

Timely personalized preparation for pregnancy has an important preventive, prognostic, clinical value for the further course of gestational processes. Pregnancy planning by expectant parents, in principle a man and a woman, becomes especially important in the conditions of the COVID-19 pandemic, taking into account the tropism of the SARS-Cov-2 (COVID-19) virus to the vascular endothelium.
 The purpose of the study was to determine the features of pre-gravid preparation of future parents after suffering from the COVID-19 disease through the use of personalized preventive measures.
 Research materials and methods. 42 women and 42 of their men of reproductive age who were sick with COVID-19 were examined. The main group is represented by 21 couples who planned pregnancy after personalized training. Pregnancy occurred spontaneously in a short time after the disease in the comparison group (21 married couples). The developed and proposed preconception preparation algorithm included a timely assessment of their somatic condition in the postcovid period, including hemostasiological blood parameters, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora, and determination of the safest term through which to rationally recommend pregnancy planning, personalized pre-gravid preparation 3-4 months before expected natural fertilization.
 Research results and their discussion. The presence of infectious processes in the body of women is a concomitant factor of the course of COVID-19 and the features of the clinical manifestations of the post-covid syndrome. Increased levels of markers of inflammation (ferritin, CRP, D-dimer) and decreased levels of vitamin D, magnesium are the basis for the pathogenetic justification of the stage of complex personalized preconception preparation.
 Conclusions. Features of the pre-gravid preparation of future parents (male/female) after having experienced the disease of COVID-19 are: 1) timely assessment of their somatic condition in the post-covid period, including hemostasiological indicators of blood, markers of inflammation (ferritin, CRP, D-dimer), detection of accompanying infectious flora and determination of the safest period through which to rationally recommend pregnancy planning; 2) use according to the indications of preventive comprehensive personalized prevention and personalized pregravid preparation 3-4 months before the expected natural fertilization, including by taking vitamin macro-microelement amino acid complexes containing Methylfolate and continuing their intake throughout the gestation period. Indicators of the blood coagulation system were monitored by trimester of pregnancy.