FEATURES OF PREGNANCY WITH VIRAL HEPATITIS B

Abstract

To date, insufficient data have been accumulated on the impact of maternal hepatitis B virus (HBV) infection on the course and outcomes of pregnancy, and data from published studies on this issue are contradictory.
 The aim of the study. Determination of the features of the course of pregnancy, the state of the fetus and the newborn in viral hepatitis B.
 Research materials and methods. 86 pregnant women with HBV were comprehensively examined (main group). 50 healthy pregnant women are included in the control group. Descriptive statistics methods used in biology and medicine were used.
 Research results. The majority (67.4%) of patients with HBV are diagnosed with the inactive carrier phase, 27.9% with the replicative phase. Among obstetric and perinatal complications in women with HBV, early preeclampsia (30.2%) and the threat of abortion (29.1%), placental insufficiency (31.4%), gestational diabetes (17.4%), anemia I are most often noted and II half of pregnancy (26.7 and 29.1%), signs of fetal distress in the form of distress (26.7%) and growth retardation (14.1%). Polyhydramnios was observed in 17.4%. 2 (2.3%) cases of early pregnancy loss (miscarriage) were recorded. 20.9% of patients with hepatitis B were delivered surgically, premature birth occurred in 14.0% of patients. High frequency of fetal distress during childbirth (18.6%) and pathological blood loss (15.1%). 26.7% of women with HBV gave birth to asphyxiated children (2.3% had severe asphyxia). In 19.7% of cases, children were born with reduced body weight, in 11.6% - with signs of hypotrophy, in 8.1% of children signs of intrauterine infection were noted. Violations of the period of neonatal adaptation in the form of gastrointestinal syndrome, muscle hypotonia, increased neuroreflex excitability, thermoregulation disorders were observed in 18.6% of children. In 2 (2.3%) children born to women with HBV in the replication phase at a high level of viral load, intrauterine HBV infection was diagnosed, which was confirmed by positive PCR at 3 and 6 months.
 Conclusions. Various obstetric and perinatal complications were observed in 38 (44.2%) pregnant women with HBV; further in-depth studies are needed to clarify the pathogenetic mechanisms of such disorders and identify risk factors.