Abstract
Aim. To study the features of piribedil use in the treatment of mild cognitive impairments in patients with chronic heart failure (CHF). Material and methods. Open randomized study of piribedil efficacy in treatment of mild cognitive impairments of the patients with CHF and ischemic heart disease was performed. Eligible patients were randomized into group of piribedil treatment or control group. Each group included 20 patients. Patients of the main group received piribedil 50 mg a day during 12 weeks. Cognitive functions were estimated by Burdon’s test, 5 and 7 subtests of Wexler before and after 12 weeks of treatment. Results. Significant improvement of cognitive tests was revealed in patients receiving piribedil at the final visit. Maximum effect of the drug was observed in younger patients, patients with increased carotid arteries intima-media thickness and increased left ventricular end-diastolic dimension. Conclusion. Piribedil significantly improves memory and attention in patients with CHF and can be used in therapy of mild cognitive impairments in these patients.
Highlights
Y.G. Shvarts1 1 Saratov State Medical University named after V.I. Razumovsky
Clinical trial of the effect of Piribedil in the treatment of the mild cognitive impairements in patients with chronic heart failure which caused by ischemic heart disease
Strachunskaja E.Ja. et al Treatment of the nondemention cognitive impairements in patients with arterial hypertension and cerebral atherosclerosis (According to the Russian multicenter study evaluating the «FUJeTE »)
Summary
Изучить особенности применения пирибедила в терапии умеренных когнитивных расстройств у пациентов с хронической сердечной недостаточностью (ХСН) ишемического генеза. Пирибедил достоверно улучшает показатели памяти и внимания у пациентов с ХСН ишемического генеза и может использоваться в терапии умеренных когнитивных расстройств у этих больных. Features of piribedil use in the treatment of mild cognitive impairments in patients with chronic heart failure N.S. Akimova1*, T.V. Martinovich1, D.G. Persashvili1, Y.G. Shvarts1 1 Saratov State Medical University named after V.I. Razumovsky.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
