Features of ovarian Brenner tumors: Experience of a single tertiary center.

Batuhan Turgay,Kazibe Koyuncu,Salih Taşkın,Uğur Fırat Ortaç

doi:10.4274/tjod.98216

Batuhan Turgay, Kazibe Koyuncu + Show 2 more

Open Access

https://doi.org/10.4274/tjod.98216

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Abstract

Objective:Brenner tumors are rare neoplasms of the ovary. The aim of this study was to investigate the clinical features of Brenner tumors.Materials and Methods:The clinical features of 22 patients who were treated in Ankara University Faculty of Medicine Obstetrics and Gynecology Department between 2005 and 2015 were evaluated retrospectively from hospital medical records.Results:The patients were aged 34 to 79 years at the time of diagnosis and the mean age was 55.1 years. Two (9.1%) patients were pre-menopausal, five (22.7%) were peri-menopausal, and 25 (68.2%) patients were postmenopausal. One patient was pregnant. Twenty of the neoplasms were benign, one was malignant, and one was both malignant and benign. There was no recurrence in the malignant cases. Six (27.2%) patients had mixed tumors consisting of Brenner tumor and another ovarian pathology. Specifically, the other component of these tumors was mucinous cystadenoma in four patients, endometriosis externa in one patient, and high-grade serous papillary cyst adenocarcinoma in one patient.Conclusion:Brenner tumors are usually incidental benign pathologic findings of surgical procedures in postmenopausal women. They can be found with other ovarian pathologies such as mucinous ovarian tumors and can coexist with other female genital tumors. Further studies are needed to completely understand the clinical features of Brenner tumors.

Highlights

Brenner tumors are a relatively rare surface epithelial neoplasm of the ovary, accounting for 1.4-2.5% of all ovarian tumors
Six (27.2%) patients had mixed tumors consisting of Brenner tumor and another ovarian pathology
Two cases (9.1%) were diagnosed as malignant Brenner tumor, and one as high-grade serous papillary cyst adenocarcinoma

Summary

Introduction

Brenner tumors are a relatively rare surface epithelial neoplasm of the ovary, accounting for 1.4-2.5% of all ovarian tumors. They are known as transitional cell tumors of the ovaries due to their histologic findings. Brenner tumors usually affect postmenopausal women, and most (99%) are benign[1,2,3,4]. They are usually unilateral; bilateral lesions are found in 5-14% of cases[2,4,5]. Brenner tumors are usually discovered incidentally, patients occasionally present with symptoms such as a palpable mass or pain[6].

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