Abstract
The presence of hypothyroidism in patients with coronary heart disease contributes to the progression of structural and functional reorganization of the heart.Aim. In order to study the features of myocardial remodeling in patients with coronary heart disease associated with hypothyroidism, 74 patients were examined.Methods and results. With the Doppler echocardiography and enzyme immunoassay the structural and functional characteristics of the heart and the levels of hormones of the pituitary-thyroid system were studied. It was found that in patients with coronary heart disease, comorbid with hypothyroidism, an increase of the end-diastolic volume, end-diastolic pressure, mass and stiffness index, deterioration of systolic function, the prevalence of concentric hypertrophy and diastolic dysfunction by the type of infringement relaxation were observed.Conclusion. The presence of correlations between TSH, free T4 and indicators of structural and functional state of the heart was revealed, which indicates the relationship with hypothyroidism and myocardial remodeling in patients with coronary heart disease.
Highlights
Наявність гіпотиреозу у хворих на ішемічну хворобу серця зумовлює її прогресування та структурно-функціональну перебудову серця
The presence of hypothyroidism in patients with coronary heart disease contributes to the progression of structural and functional reorganization of the heart
The presence of correlations between TSH, free T4 and indicators of structural and functional state of the heart was revealed, which indicates the relationship with hypothyroidism and myocardial remodeling in patients with coronary heart disease
Summary
With the Doppler echocardiography and enzyme immunoassay the structural and functional characteristics of the heart and the levels of hormones of the pituitary-thyroid system were studied. It was found that in patients with coronary heart disease, comorbid with hypothyroidism, an increase of the end-diastolic volume, end-diastolic pressure, mass and stiffness index, deterioration of systolic function, the prevalence of concentric hypertrophy and diastolic dysfunction by the type of infringement relaxation were observed
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